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RESEARCH PEOPLE LAB MEMBERS ALUMNI GALLERY PUBLICATIONS DATA & CODE CONTACT Fischer Laboratory - Structural Biology Welcome to the Fischer Lab The Ubiquitin Proteasome System is involved in virtually any cellular process and frequently implicated in human diseases. The Fischer lab combines structural biology, cell biology, and high throughput biology approaches to understand the mechanistic principles that govern signaling through the ubiquitin proteasome system. We leverage these insights to propose and test new avenues of therapeutic intervention, such as targeted protein degradation or SPLiNTs. Our work has contributed to the now widespread application of targeted protein degradation in drug development and as a powerful tool to study biology. We cultivate a multi-disciplinary and highly collaborative approach to science to tackle fundamental questions in biology and pharmacology. We also work closely with the DFCI Center for Protein Degradation on the development of novel therapeutics. The Fischer Lab is part of: Department of Cancer Biology - Dana Farber Cancer Institute Department of Biological Chemistry & Molecular Pharmacology (BCMP) - Harvard Medical School The Chemical Biology Initiative - Dana Farber Cancer Institute The Center for Protein Degradation - Dana Farber Cancer Institute ​ HOME | RESEARCH | TEAM | PUBLICATIONS | CONTACT ©2015 Structural Biology at Dana-Farber Cancer...